Our Services
Pre-clinical services
PANGAEA LAB integrates advanced molecular diagnostics with preclinical cancer research to generate clinically relevant, translational insights that support oncology drug development and biomarker strategies.
Our multidisciplinary team combines expertise in tumor biology, molecular profiling and functional validation, enabling a seamless connection between patient-derived data and preclinical models.
In-house and through partnerships we perform comprehensive pathology, molecular biology, in-vitro and in-vivo techniques:
- Study of in-vitro effects of drugs and vaccines
- 2D and 3D cell culturing
- MTT proliferation assays
- Flow cytometry
- Colony formation, migration and invasion assays
- Generation of primary cultures derived from patient material (fresh biopsies and malignant effusions) and private collection of over 300 cellular models with clinically relevant molecular alterations.
- Service & idea providers for the development of new anti-cancer drugs
- Characterization of different cellular models using molecular techniques (FISH, NGS etc.)
- Development of cell lines resistant to drugs on the market
- In-vivo mice models
- Biomarker Discovery linked to drug sensitivity
- Gene silencing (lentivirus transfection, CRISPR)
PATIENT-DERIVED & RESISTANCE MODELS
One of our key differentiators is the development and use of patient-derived models that closely reflect real tumor biology and clinical behavior.
We provide:
- Generation of primary cultures from patient samples (fresh biopsies and malignant effusions), linked to clinical and molecular data.
- A proprietary collection of 300+ characterized cellular models with clinically relevant alterations.
- Development of drug-resistant cell lines, modeling acquired resistance observed in patients.
DRUG DEVELOPMENT & FUNCTIONAL STUDIES
We support pharmaceutical and biotech partners across multiple stages of drug development by providing:
- Drug efficacy and mechanism of action studies.
- Evaluation of combination therapies.
- Resistance modeling and evolution studies.
- Patient stratification support through translational models.
EXPERIMENTAL CAPABILITIES
- 2D and 3D cell culture systems, including organoid-based models.
- MTT proliferation assays and functional assays.
- Colony formation, migration and invasion assays.
- Flow cytometry-based analysis.
- Molecular characterization using NGS, FISH and other advanced platforms.
- Biomarker discovery and validation linked to drug response.
- Gene editing and silencing (CRISPR, lentiviral systems).
- In vivo mouse models.
ADVANCED MOLECULAR & GENETIC TOOLS
We integrate molecular characterization and genetic manipulation techniques to deepen biological understanding:
- Molecular profiling using NGS, FISH and other advanced platforms.
- Biomarker discovery linked to drug sensitivity and resistance.
- Gene silencing and editing (lentiviral transduction, CRISPR technologies).
In Vivo Models
We complement our in vitro capabilities with in vivo mouse models, enabling the evaluation of therapeutic strategies in physiologically relevant systems.
TRANSLATIONAL IMPACT
Our approach goes beyond experimentation: we connect preclinical findings with clinical data to generate actionable insights for:
- Drug development programs.
- Biomarker identification and validation.
- Clinical trial design and patient selection.